What is methadone?
Methadone is an opioid medication. An opioid is sometimes called a narcotic. Methadone reduces withdrawal symptoms in people addicted to heroin or other narcotic drugs without causing the “high” associated with the drug addiction.
Methadone is used as a pain reliever and as part of drug addiction detoxification and maintenance programs. It is available only from a certified pharmacy.
You should not use methadone if you have severe asthma or breathing problems, or a blockage in your stomach or intestines.
Methadone can slow or stop your breathing, and may be habit-forming. MISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.
Taking this medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.
Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.
Methadone may cause a life-threatening heart rhythm disorder. Call your doctor at once if you have a headache with chest pain and severe dizziness, and fast or pounding heartbeats.
Before taking this medicine
You should not use methadone if you are allergic to it, or if you have:
severe asthma or breathing problems; or
a blockage in your stomach or intestines.
this medicament may cause a life-threatening heart rhythm disorder. Your heart function may need to be checked during treatment.
Some medicines can interact with methadone and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take stimulant medicine, herbal products, or medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.
To make sure this medicine is safe for you, tell your doctor if you have ever had:
heart problems, long QT syndrome (in you or a family member);
breathing problems or lung disease;
a head injury, brain tumor, or seizures;
drug or alcohol addiction, or mental illness;
liver or kidney disease;
problems with your gallbladder, pancreas, or thyroid; or
if you use a sedative like Valium (diazepam, alprazolam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Versed, Xanax, and others).
If you use this medicament while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.
Do not breast-feed while taking methadone. This medicine can pass into breast milk and cause drowsiness, breathing problems, or death in a nursing baby.
How should I use methadone?
this medicament may be habit-forming, even at regular doses. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Selling or giving away methadone is against the law.
Follow all directions on your prescription label. Methadone can slow or stop your breathing, especially when you start using this medicine or whenever your dose is changed. Never use this medicine in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in relieving your pain.
Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
Dissolve the dispersible tablet in water, orange juice, or other citrus-flavored non-alcoholic beverage.
Never use this medicament tablets or liquid to make a mixture for injecting the drug into your vein. This practice has resulted in death with the misuse of prescription drugs.
When methadone is used as part of a treatment program for drug addiction or detoxification, your doctor may recommend that this medicine be given to you by a family member or other caregiver.
You should not stop using this medicine suddenly. Follow your doctor’s instructions about tapering your dose.
Store at room temperature away from moisture and heat.
Keep the medication in a place where others cannot get to it. Methadone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.
Do not keep leftover pills or liquid. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush any unused pills or liquid medicine down the toilet.
What should I avoid while using methadone?
Do not drink alcohol. Dangerous side effects or death could occur.
this medicament may impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls, accidents, or severe injuries.
Grapefruit and grapefruit juice may interact with this medicament and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.
Methadone side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Like other opioid medicines, this medicament can slow your breathing. Death may occur if breathing becomes too weak. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.
Call your doctor at once if you have:
weak or shallow breathing;
a light-headed feeling, like you might pass out;
symptoms of a life-threatening heart rhythm disorder – a headache with chest pain and severe dizziness, and fast or pounding heartbeats; or
low cortisol levels – nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Methadone is more likely to cause breathing problems in older adults and people who are severely ill, malnourished, or otherwise debilitated.
Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.
Common methadone side effects may include:
nausea, vomiting; or
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